Status:
SUSPENDED
Upper GI Serial Tumour Biopsies
Lead Sponsor:
The Christie NHS Foundation Trust
Conditions:
Oesophageal Cancer
Gastric Cancer
Eligibility:
All Genders
18-100 years
Brief Summary
This is a prospective translational research study in which tumour samples, blood samples and other biospecimens will be requested from patients with locally advanced or metastatic malignant oesophage...
Detailed Description
This is a prospective, non-randomised, non-interventional, translational research study in which patients with locally advanced or metastatic oesophageal and gastric carcinoma will be asked to donate ...
Eligibility Criteria
Inclusion
- Age of 18 years or more.
- Patients must have given written informed consent.
- Evidence of locally advanced or metastatic oesophageal and gastric carcinoma, i.e. stage III or IV disease.
- Accessible tumour that can be safely biopsied using radiological or surgical techniques (if consenting to part A).
- Full blood count and coagulation tests within acceptable parameters (if consenting to part A).
Exclusion
- Inability to provide informed consent.
- History of significant bleeding disorder (patients on anticoagulation are eligible if the anticoagulation can be safely managed to allow fresh tumour biopsies and blood sampling).
- History of HIV, Hepatitis B/C or other transmissible human disease.
- Any conditions where research biopsies or blood sampling may increase risk of complications for the patient and/or investigator, including high risk groups such as intravenous drug users.
Key Trial Info
Start Date :
January 25 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05233007
Start Date
January 25 2022
End Date
October 1 2028
Last Update
February 8 2024
Active Locations (1)
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1
The Christie Hospital NHS Foundation Trust
Manchester, Greater Manchester, United Kingdom, M20 4BX