Status:
UNKNOWN
Identification of the Causative Drug in Drug-induced Acute Interstitial Nephritis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Acute Interstitial Nephritis
Drug-Induced Interstitial Nephritis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Drug-induced acute interstitial nephritis (DAIN) is a rare entity characterized by acute renal failure linked to inflammation of the renal parenchyma secondary to allergenic drug exposure. Treatment i...
Detailed Description
Acute interstitial nephritis (AIN) is a nosological entity characterized by the presence of an inflammatory infiltrate and edema in the renal interstitium responsible for acute renal failure. AIN repr...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Acute renal failure with an eGFR \< 60 ml/min/1.73m2 by CKD-EPI managed in the participating centers in the study
- Histologically proven DAIN by renal biopsy (anatomopathological reading in each center according to local habits): presence of an infiltration of inflammatory cells (lymphocytes, monocytes, plasmocytes, eosinophils) in the interstitium accompanied by a variable degree of interstitial edema and fibrosis
- Successful diagnosis of DAIN with identification of one or more attributable drugs
- Signed consent
- Membership in a social security plan or entitled person
Exclusion
- Anatomic-clinical suspicion of AIN of infectious or autoimmune cause or associated with systemic diseases (Sjögren's syndrome, sarcoidosis, tubulointerstitial nephritis syndrome and uveitis, systemic lupus, IgG4-associated disease)
- Kidney transplant patients
- Current immunosuppressive treatment at the time of allergological testing (test results not interpretable)
- Participation in other interventional research
- Patient under state medical assistance
- Patient deprived of liberty or under legal protection
- Pregnancy
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2024
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT05233241
Start Date
July 1 2022
End Date
January 1 2024
Last Update
June 30 2022
Active Locations (1)
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1
Nephrology department, Tenon hospital - APHP
Paris, France, 75020