Status:
UNKNOWN
DART: Diagnostic-CT-Enabled Planning: A Randomized Trial in Palliative Radiation Therapy
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Advanced Cancer Requiring Palliative Radiation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of this trial is to assess the efficacy, acceptability, and scalability of diagnostic-CT-enabled planning, compared to conventional CT simulation planning.
Eligibility Criteria
Inclusion
- Age 18 years or older
- Able to provide informed consent
- Patient has consented to PRT to bone/soft tissue metastases or primary targets in the thorax, abdomen, or pelvis and RO will use simple planning techniques (i.e. parallel-opposed pair or direct field beam arrangement)
- Patient will be scheduled for same-day simulation and treatment (if randomized to Arm 1)
- Patient has a pre-existing and recent (i.e. within 4 weeks of time of enrollment) diagnostic CT or CT-fused scan with full visualization of the region-of-interest which has been acquired from an approved diagnostic scanner
- Patient positioning scan is deemed acceptable and reproducible (e.g., patient is lying supine and relatively flat, there is no/minimal motion blur, ect.)
- Intravenous (IV)/oral contrast in the region-of-interest is permitted as long as it does not create artifact which obscured the target volume (density override calculations may be required)
Exclusion
- Any contraindication to receiving radiation
- Oncologic emergencies and/or on-call cases
- Pregnant or lactating women
- Cases requiring composite dosimetric planning to account for previous radiotherapy or extended distance set-up
Key Trial Info
Start Date :
June 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2023
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT05233904
Start Date
June 8 2022
End Date
August 1 2023
Last Update
June 13 2022
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9