Status:
UNKNOWN
Mindfulness-Based Cognitive Therapy for Depressed IAPT Non-Responders
Lead Sponsor:
Sussex Partnership NHS Foundation Trust
Collaborating Sponsors:
King's College London
University of Exeter
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
If not treated sufficiently, Major Depression tends to take a recurrent or chronic lifetime course that is associated with a significantly increased risk for physical and neurodegenerative disorders. ...
Detailed Description
Major Depression represents a pressing challenge for health care. The disorder is not only highly prevalent but also shows many characteristics of a progressive disorder. If not treated sufficiently, ...
Eligibility Criteria
Inclusion
- Inclusion Criteria will be
- non-response to a minimal effective dose of high intensity treatment in IAPT (at least 12 sessions, in line with NICE draft guideline suggestions) defined in line with the caseness threshold adopted by IAPT as a Patient Health Questionnaire-9 (PHQ-9) score of 10 or higher
- meeting criteria for a current episode of Major Depression according to DSM-5 as assessed through the Mini International Neuropsychiatric Interview for DSM-5
- age 18 or older
- access to a working internet connection to participate in videoconferencing assessments and interventions
- Potential participants will be excluded if
- based on the judgment of their IAPT therapist they are eligible for, would be seen by, and their needs would be best met by secondary care specialist services
- they present with a level of risk to self or others that cannot be safely managed in a primary care service context (i.e. active suicidal plans), a history of psychosis or psychotic symptoms, a current episode of mania, alcohol or substance abuse or dependence within the past 3 months, current post-traumatic stress disorder, obsessive-compulsive disorder or eating disorder.
- they suffer from any other significant disease or disorder that may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial
- if they have an insufficient ability to understand or read English.
- Patients who are currently taking antidepressant medication will be allowed into the trial and medication use will be documented for statistical analysis.
Exclusion
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
234 Patients enrolled
Trial Details
Trial ID
NCT05236959
Start Date
January 1 2021
End Date
December 31 2022
Last Update
February 11 2022
Active Locations (4)
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1
Mood Disorders Centre, University of Exeter
Exeter, Devon, United Kingdom
2
Sussex Partnership NHS Foundation Trust
Brighton, Sussex, United Kingdom
3
Devon Partnership NHS Trust
Exeter, United Kingdom
4
South London and Maudsley NHS Foundation Trust
London, United Kingdom