Status:
RECRUITING
Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)
Lead Sponsor:
National Cancer Institute (NCI)
Conditions:
Neuroendocrine Tumors
Carcinoma, Neuroendocrine
Eligibility:
All Genders
18-120 years
Brief Summary
Background: Neuroendocrine neoplasm (NENs)are rare cancers arising from the neuroendocrine cells and can affect almost any part of the body. They vary from low grade neuroendocrine tumors (NETs) to h...
Detailed Description
Background: * Neuroendocrine neoplasms (NENs) are divided into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). These are rare malignancies occurring for example in the gastrointest...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Age \>= 18 years old
- The ability of the participant to understand and the willingness to sign a written consent document.
- Participants with the documentation of:
- histological or cytological confirmation of NENs or adrenocortical cancer
- OR
- -biochemical evidence of neuroendocrine tumor (serum/urinary) based on elevated levels of chromogranin A, pancreatic polypeptide, neuron-specific enolase, vasoactive intestinal polypeptide, serotonin (urinary 5-hydroxyindoleacetic acid (5-HIAA)), gastrin, somatostatin, catecholamines, metanephrines, calcitonin, fasting insulin, Cpeptide (proinsulin), glucagon, anterior pituitary hormones
- OR
- -Suspicion of NEN (from any site/origin) on axial imaging (computed tomography (CT)/ magnetic resonance imaging (MRI) / fluorodeoxyglucose (FDG) positron emission tomography (PET) / 68Ga-Dotatate scan
- OR
- -a germline genetic variant that predisposes to NETs including ACC.
- EXCLUSION CRITERIA:
- None
Exclusion
Key Trial Info
Start Date :
April 25 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2032
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT05237934
Start Date
April 25 2022
End Date
December 31 2032
Last Update
November 12 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892