Status:
COMPLETED
Evaluating Performance and Safety of the Medical Device Jalucomplex in the Treatment of Facial and Neck Tissue Defects
Lead Sponsor:
I.R.A. Istituto Ricerche Applicate S.p.A.
Collaborating Sponsors:
Opera CRO, a TIGERMED Group Company
Conditions:
Cicatrix
Lipodystrophy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The Research Question of the present study is the following: in a population of men and women presenting facial and neck dermal tissue defects (scars, hypertrophic scars, depressed plaques, and lipody...
Detailed Description
Jalucomplex® action is to increase the volume of dermal-epidermal tissue, based on the natural ability of hydrophilic hyaluronic acid molecules to bind to an amount of water many times greater than th...
Eligibility Criteria
Inclusion
- Men or women with age ≥ 18 and ≤ 65 years.
- Patients with facial and neck dermal tissue defects (scars, hypertrophic scars, depressed plaques, and lipodystrophy defects), caused both by pathologies or trauma, seeking tissue augmentation treatment and willing to receive HA Filler.
- Patients who agree to discontinue any other dermatological treatment and procedures during the study.
- Patients willing to provide signed informed consent to clinical investigation participation.
- Patients able to communicate adequately with the Investigator and to comply with the requirements for the entire study.
Exclusion
- Past or current bleeding disorders.
- Use of aspirin and antiplatelet agents a week prior to treatment.
- Prior or planned use of topical injection to the face and the neck (steroid, retinoid: applicable only to drugs, not applicable to cosmetics), within 4 weeks prior to screening or during this study (steroid ointment for therapeutic objectives is allowed for short -term use of ≤14 consecutive days.).
- Use of immunosuppressive, chemotherapies, or systemic corticosteroids within 12 weeks from screening.
- History of anaphylaxis or severe complicated allergy symptoms.
- Clinically significant cardiovascular, digestive, respiratory, endocrine, or central nervous system disorders or previous mental disorders that may significantly affect the study.
- Known hypersensitivity skin reaction to hyaluronic acid or hypersensitivity skin reaction to the investigational device based on intradermal test results at visit 1.
- Evidence or history of autoimmune disease or compromised immune system.
- Treatment with anticoagulants, thrombolytics, or platelet inhibitors within 1 week prior to study participation.
- Prior permanent fillers or fat graft procedures around facial and neck dermal tissue defects.
- Facial and neck dermal tissue defects correction procedures (e.g., botulinum toxin A injection, face lift, soft tissue augmentation, medium-depth peel, dermal photo-rejuvenation, etc.) around infraorbital region within 6 months prior to study participation.
- History of hypersensitivity to local anaesthetic of amide type or HA.
- History of keloid formation on the face and the neck.
- Evidence of active infection on the face and the neck.
- Wound, skin disorder or infection around facial and neck dermal tissue that may affect the efficacy assessment.
- Pregnant woman, lactating woman, and man or woman of childbearing potential who is planning a pregnancy or is unwilling to use appropriate methods of contraception\* during the study. \*Methods of contraception: hormonal contraceptive, intrauterine device or intrauterine system, double barrier method (condom with spermicide/diaphragm or cervical cap with spermicide), surgical sterilization (vasectomy, tubal ligation, etc.).
- Need to exposure to the sun, UV rays and extreme conditions of heat for at least a week after the treatment.
- Need to have direct or indirect contact with quaternary ammonium salts during the study.
- As with all dermal filler procedures, the product should not be used in vascular rich areas. Using the product at sites such as Glabella and nose may inadvertently be injected into the blood vessels, resulting in symptom of vessel occlusion such as colour vision deficiency and blindness.
- Patients with illness, or other medical condition that, in the opinion of the investigator, would compromise participation or be likely to lead to hospitalization during the study.
- Participation in an interventional clinical study or administration of any investigational agents in the previous 30 days.
Key Trial Info
Start Date :
March 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 7 2022
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05239351
Start Date
March 7 2022
End Date
July 7 2022
Last Update
October 24 2022
Active Locations (1)
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1
SCM Dr. Rosu
Timișoara, Timiș County, Romania, 300425