Status:
COMPLETED
OREIOS International Study
Lead Sponsor:
AstraZeneca
Conditions:
Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Brief Summary
Considering the treatment landscape with its dynamic algorithms and new approaches of sequencing, it is important to identify patient management patterns and survival outcomes arising from the current...
Detailed Description
Patients with unresectable HCC are an extremely heterogeneous population, with several coexisting risk factors like underlying hepatic dysfunction, extrahepatic metastases, and macrovascular invasion ...
Eligibility Criteria
Inclusion
- Adult female or male patients aged ≥18 years or 'adults' according to the age of majority as defined by the local regulations at index diagnosis
- Patients or legal representative (unless a waiver is granted) willing and be able to provide informed consent according to local regulations. For deceased patients at study entry, informed consent is not mandatory.
- Patients with radiologically or histopathologically confirmed diagnosis (at index date) of unresectable BCLC stage B HCC, not considered eligible for initial loco-regional therapya or stage C advanced or metastatic disease, between 01 January 2017 and 31 December 2019.
- Availability of at least 12 months of follow-up data (from the index date) in the medical records at the participating site, unless patient died within the first 12 months of diagnosis.
Exclusion
- Patients with BCLC stage D HCC at index diagnosis
- Patients with concomitant cancer, at the time of diagnosis of unresectable HCC, except for the nonmetastatic nonmelanoma skin cancers or in situ or benign neoplasms; a cancer is considered concomitant if it occurs within 5 years of HCC diagnosis.
Key Trial Info
Start Date :
February 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 12 2023
Estimated Enrollment :
1127 Patients enrolled
Trial Details
Trial ID
NCT05239507
Start Date
February 1 2022
End Date
March 12 2023
Last Update
March 13 2024
Active Locations (21)
Enter a location and click search to find clinical trials sorted by distance.
1
Research Site
Porto Alegre, Rio Grande do Sul, Brazil, 90560030
2
Research Site
São Paulo, Brazil, 1246000
3
Research Site
Alexandira, Egypt
4
Research Site
Asyut, Egypt