Status:
UNKNOWN
VExUS-guided Fluid Management in Patients With Acute Kidney Injury in the Intensive Care Unit
Lead Sponsor:
Hospital de Clinicas de Porto Alegre
Conditions:
Acute Kidney Injury
Renal Insufficiency, Acute
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A quasi experimental study that aims to verify whether the incorporation of VExUS in patients with AKI in the Intensive Care Unit (ICU) may prompt tailored interventions to increases the number of day...
Detailed Description
Fluid overload is associated with organ dysfunction, such as Acute Kidney Injury (AKI), and increased mortality. It remains unclear if fluid overload is merely an epiphenomenon in critically ill patie...
Eligibility Criteria
Inclusion
- Non-elective ICU admission
- Severe acute kidney injury (AKI) defined either: A ≥ 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization OR Urine output \< 6.0 mL/kg over the preceding 12 hours
Exclusion
- Life-threatening indication of RRT (defined as intractable hyperkalaemia, acidosis, uraemic symptoms) at Day 0
- RRT before recruitment
- Use of Extracorporeal membrane oxygenation (ECMO)
- Hepatic cirrhosis or other condition with portal hypertension
- Lack of commitment to provide RRT as part of limitation of ongoing life support
- Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate \< 30 mL/min/1.73 m2 or chronic RRT
- Refusal to sign the informed consent form
Key Trial Info
Start Date :
January 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT05240833
Start Date
January 7 2022
End Date
December 31 2022
Last Update
February 15 2022
Active Locations (1)
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1
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903