Status:
RECRUITING
The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)
Lead Sponsor:
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Conditions:
Stroke, Ischemic
Sleep Disorder
Eligibility:
All Genders
18-80 years
Brief Summary
The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients. It is designed as an observational...
Detailed Description
In the retrospective arm of the study, the routinely collected data of patients admitted to the stroke unit with acute ischemic stroke (from 2018 till 2022) will be evaluated. In the prospective longi...
Eligibility Criteria
Inclusion
- acute (symptom onset to admission \<1 days) ischemic stroke
- ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery
- age 18-80 years
- moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS\>=5)
- intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable)
- informed consent
Exclusion
- secondary parenchymal hemorrhage (\>hemorrhage index -2)
- clinically unstable or life-threatening conditions
- known progressive neurological diseases
- known psychiatric diseases
- concomitant benzodiazepine medication
- drug or alcohol abuse
- pregnancy
- disability to participate in the study
- congestive heart failure with reduced ejection fraction (\<=45%) or New York Heart Association (NYHA) classification III-IV functional class
Key Trial Info
Start Date :
May 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT05242393
Start Date
May 1 2018
End Date
December 31 2026
Last Update
August 8 2025
Active Locations (1)
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1
Almazov National Medical Research Centre
Saint Petersburg, Russia, 197341