Status:
COMPLETED
A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
Lead Sponsor:
Genentech, Inc.
Conditions:
Multiple Myeloma
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with a multiple myeloma (MM)-targeting monoclonal antibody capable of inducing antibody-de...
Eligibility Criteria
Inclusion
- Life expectancy of at least 12 weeks
- Measurable disease, as defined by the protocol
- Participants must have received a minimum of 3 prior lines of therapy, including at least one PI, one IMiD, and an anti-CD38 monoclonal antibody
- Best response of stable disease or better with at least one prior anti-CD38 monoclonal antibody containing line of treatment
Exclusion
- Any anti-cancer therapy within 3 weeks prior to initiation of study treatment, with exceptions defined by the protocol
- Prior allogeneic stem cell or solid organ transplantation
- Autologous stem cell transplantation within 100 days prior to initiation of study treatment
- Significant cardiovascular disease
- Known clinically significant liver disease
- Active or history of autoimmune disease or immune deficiency
- Known active infection requiring IV anti-microbial therapy within 14 days prior to first study drug administration
- Primary or secondary plasma cell leukemia
- Current CNS involvement by MM
- Other protocol defined inclusion/exclusion criteria may apply
Key Trial Info
Start Date :
April 28 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 10 2024
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT05243342
Start Date
April 28 2022
End Date
July 10 2024
Last Update
February 17 2025
Active Locations (7)
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1
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
2
Alfred Hospital
Melbourne, Victoria, Australia, 3004
3
Odense Universitetshospital
Odense C, Region Syddanmark, Denmark, 5000
4
Sygehus Lillebælt, Vejle
Vejle, Region Syddanmark, Denmark, 7100