Status:
COMPLETED
Comparing Chemoprevention Approaches for School-based Malaria Control
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
Kamuzu University of Health Sciences
Doris Duke Charitable Foundation
Conditions:
Malaria,Falciparum
Anemia in Children
Eligibility:
All Genders
6+ years
Phase:
PHASE4
Brief Summary
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent screening and treatment (IST) - students will receive tr...
Detailed Description
Students will be enrolled in a single primary school in Machinga District, Malawi. The intervention will be conducted every 6-weeks during the two school terms which coincide with peak malaria transmi...
Eligibility Criteria
Inclusion
- Students (enrolled in the primary intervention)
- Currently enrolled in the study school
- Plan to attend the study school for the remainder of the school year
- Parent/guardian available to provide written informed consent Household members (enrolled in the Household Prevalence survey)
- Slept in the household for most nights in the last month
- Age 6 months or older
- For minors, parent/guardian available to provide written informed consent
Exclusion
- Students (enrolled in the primary intervention)
- Current evidence of severe malaria or danger signs
- Known adverse reaction to the study drugs
- History of cardiac problems or fainting
- Taking medications known to prolong QT
- Family history of prolonged QT
- Girls 10 years old and older with epilepsy or psoriasis Household members (enrolled in the Household Prevalence survey)
- Household with more than one school-age child enrolled in the study
- Current evidence of severe malaria or danger signs
Key Trial Info
Start Date :
February 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 26 2022
Estimated Enrollment :
746 Patients enrolled
Trial Details
Trial ID
NCT05244954
Start Date
February 1 2022
End Date
August 26 2022
Last Update
November 15 2022
Active Locations (1)
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1
Kamuzu University of Health Sciences
Blantyre, Malawi