Status:
UNKNOWN
Trauma and Critical Care Exposure Examined With PET (TRAPETS)
Lead Sponsor:
Karolinska University Hospital
Conditions:
Cognitive Dysfunction
Critical Illness
Eligibility:
All Genders
20-60 years
Brief Summary
The overall aim is to examine the impact of trauma and critical illness on the brain, peripheral immune system and cognition. This is a prospective study where a study group exposed to trauma and inte...
Detailed Description
Background Cognitive impairment is a common problem after an episode of critical illness. Cognitive impairment occurs regardless of diagnosis of admission and this profound impairment is comparable to...
Eligibility Criteria
Inclusion
- Patients 20-60 years of age.
- Trauma with an ISS score of ≥15
- Informed consent
Exclusion
- Patient´s refusal to participate in the trial
- Any traumatic brain or spinal injury prior to admission
- Disabling neuropsychiatric disorder (dementia-diagnosis, Mb Alzheimer, Mb Parkinson, schizophrenia or severe mental depression prior to ICU admission)
- Any preadmission history of stroke with neurological sequelae
- Co-morbidities prior to ICU admission such as severe cardiac, hepatic, hematological or renal impairment
- Terminal phase of chronic disease or malignancy
- High-dose steroid treatment before ICU admission or during ICU care
- Presumed uncooperativeness or legal incapacity
Key Trial Info
Start Date :
April 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05245253
Start Date
April 1 2022
End Date
September 1 2025
Last Update
December 16 2022
Active Locations (1)
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1
Karolinska University Hospital, Perioperative Medicine and Intensive Care
Stockholm, Sweden, 17176