Status:
UNKNOWN
Propofol/Dexmedetomidine Versus Desflurane Effects on Post Hepatectomy Hepatocellular Injury
Lead Sponsor:
Ain Shams University
Conditions:
Hepatectomy
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
This study will compare the effects of propofol/dexmedetomidine versus desflurane for maintenance of general anesthesia on hepatocellular injury in patients undergoing partial hepatectomy.
Detailed Description
Postoperative impairment of liver function is common after hepatectomy. It may be caused by surgical trauma, loss of hepatic mass, stress response, hepatic oxygen deprivation, infection and drug toxic...
Eligibility Criteria
Inclusion
- Patients American Society of Anesthesiologists physical status (ASA) I to II.
- Patients Child Pugh classification A to B.
- Both sexes.
- Aged between 18 years and 70 years
- Scheduled for more than 1 segment hepatectomy.
Exclusion
- Patients with Child Pugh classification C.
- Patients younger than18 years old or older than 70 years old
- Patients performed additional ablation therapies (cryosurgery or radiofrequency ablation).
- Prior liver resection for donation.
- Scheduled resection not requiring inflow occlusion (Pringle's maneuver).
- Hypersensitivity to any of the used drugs.
Key Trial Info
Start Date :
June 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05246371
Start Date
June 1 2021
End Date
November 1 2023
Last Update
January 18 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Ain Shams University
Cairo, Egypt, 11591