Status:
UNKNOWN
Feasibility Study of Lidocaine Infusion During Bowel Cancer Surgery for Cancer Outcome
Lead Sponsor:
Imperial College London
Conditions:
Colorectal Cancer
Quality of Life
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This feasibility (small) study aims to see if it is possible to run a large study looking at the effect of lidocaine on large bowel cancer recurrence after surgery in the NHS hospitals.
Detailed Description
Strong preclinical evidence suggests that lidocaine, a type of local anaesthetic commonly used, could potentially reduce cancer recurrence if given during cancer surgery. This study will evaluate the ...
Eligibility Criteria
Inclusion
- Age 18 and above, undergoing laparoscopic surgery with stage 2 or 3 colon cancer
- Age 18 and above, undergoing laparoscopic surgery with stage 2 or 3 rectal cancer
- Ability and willingness to consent
Exclusion
- Stage 1 and stage 4 colon or rectal cancer
- Palliative surgery with no curative intent
- Extensive comorbidities, i.e. American Society of Anesthesiologists (ASA) Score IV
- Patients with known or suspected allergy to lidocaine
- Patients who are currently pregnant\* or breastfeeding
- Patients who are likely to have adverse effects from the accumulation of intravenous lidocaine:
- current liver disease with a liver function outside the normal laboratory range
- current renal failure (eGFR \<30)
- epilepsy
- cardiac conduction abnormalities based on history and confirmed by electrocardiogram
Key Trial Info
Start Date :
February 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 15 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05250791
Start Date
February 2 2023
End Date
September 15 2024
Last Update
June 9 2023
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom
2
Imperial College Healthcare NHS Trust
London, United Kingdom