Status:
UNKNOWN
Cardiac Substructure Radiation Dose and Early Clinical Monitoring of Stage N2-3 Non-Small Cell Lung Cancer
Lead Sponsor:
Guizhou Medical University
Conditions:
Non-small Cell Lung Cancer
Eligibility:
All Genders
18-80 years
Brief Summary
Calculating which cardiac substructure accepting with the highest radiation dose by conventional radiotherapy, then to investigate the relationship between the changes of global longitudinal strain or...
Detailed Description
All patients receive intensity-modulated radiotherapy (IMRT). The prescription dose of PTV is 60-70Gy，Troponin I, troponin T, hypersensitive troponin, brain natriuretic peptide and NT-proBNP are detec...
Eligibility Criteria
Inclusion
- Patients at TNM stage N2-N3 NSCLC confirmed by histopathology or cytology using IASLC International TNM staging standard (8th edition)
- KPS score \>80; Aged 18 to 75 year-old
- No contraindications to radiotherapy
- No history of heart disease before treatment
- Patients receiving intensity modulated radiation therapy (IMRT)
- Patients receiving PTV at a prescription dose of 60-70Gy by IMRT
- Patients receiving radiotherapy alone and concurrent chemoradiotherapy
Exclusion
- Patients with pleural effusion
- Patients with serious medical illness or infection
- Patients with acute myocardial infarction within 6 months
- In patients with NYHA grade 3-4, baseline LVEF before radiotherapy is below 59%
- Patients with congenital heart diseases, valvular diseases and arrhythmia
- Patients with pericardial effusion
- Patients receiving immunotherapy and drug targeted therapy
- Patients with a history of anthracycline use
Key Trial Info
Start Date :
February 28 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05252065
Start Date
February 28 2022
End Date
December 30 2022
Last Update
February 23 2022
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