Status:
COMPLETED
The Effects of Immobilisation and Exercise on Homeostatic Plasticity Mechanisms in Healthy Participants
Lead Sponsor:
Aalborg University
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Homeostasis is important for maintaining a stable equilibrium of e.g., blood pressure, hormonal release, and release of neurotransmitters. Within the healthy brain, homeostatic plasticity mechanisms e...
Detailed Description
The aim of this study is to investigate the impact of upper limb immobilisation and physical exercise of the hand on homeostatic plasticity in healthy individuals. The study will be performed as a ra...
Eligibility Criteria
Inclusion
- o Healthy, aged between 18-60 years, right-handed, and can speak, read, and understand Danish or English
Exclusion
- Pregnant or breastfeeding
- Regular use of cannabis, opioids or other drugs (except contraceptives)
- Current or previous neurologic, musculoskeletal, mental, or other illnesses (e.g. brain or spinal cord injuries, degenerative neurological disorders, epilepsy, major depression, cardiovascular disease, chronic lung disease, etc.)
- Current or previous chronic or recurrent pain condition
- Current regular use of analgesic medication or other medication which may affect the trial (including paracetamol and NSAIDs)
- Lack of ability to cooperate
- Recent history of acute pain particularly in the lower limbs (unless related to low back pain in patients included in sub-project 6)
- Abnormally disrupted sleep in 24 hours preceding experiment
- Any medical or other condition (i.e. musculoskeletal, cardiorespiratory, neurological, etc.)
- Contraindications to TMS application (history of epilepsy, metal implants in head or jaw, etc.)
- Unable to pass the "Transcranial Magnetic Stimulation Adult Safety Screen" or tDCS screening questionnaire
Key Trial Info
Start Date :
February 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT05252247
Start Date
February 15 2022
End Date
December 31 2022
Last Update
February 6 2023
Active Locations (1)
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1
Aalborg University
Aalborg, North Denmark, Denmark, 9220