Status:
RECRUITING
Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Lymphatic System
Eligibility:
FEMALE
18+ years
Brief Summary
Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female ...
Detailed Description
Breast Cancer Related Lymphedema (BCRL) affects 1.2 million patients in the United States and has no cure. The symptoms of lymphedema include fatigue, tightness, pain, and life-threatening infections....
Eligibility Criteria
Inclusion
- Female
- History of breast cancer treatment including ALND - defined by removal of \>=10 lymph nodes - more than 2 years before study participation
- Ability to understand the protocol and willingness to participate
- At least 18 years of age
Exclusion
- Prior history of bilateral lymph node surgery
- Prior history of other surgical procedures of the affected upper extremity besides the axillary management for breast cancer treatment
- Prior history of chronic inflammatory conditions (e.g. rheumatoid arthritis)
- Prior history of filarial infections
- Prior history of lymphedema
- Patient-reported pregnancy
- Patients who are breastfeeding
- Iodine allergy
- Prior history of upper extremity deep vein thrombosis
- Prior history of congestive heart failure
- Prior history of venous thoracic outlet syndrome
- Current active cancer
Key Trial Info
Start Date :
April 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT05253352
Start Date
April 1 2022
End Date
December 1 2025
Last Update
October 17 2025
Active Locations (1)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215