Status:
RECRUITING
Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001
Lead Sponsor:
University of Nebraska
Collaborating Sponsors:
BioMimetix JV, LLC
Conditions:
Rectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
In this Phase 2 study, we will conduct an efficacy and safety study of the combination of investigational drug BMX-001, with short-course radiotherapy (SCRT) or long-course chemoradiotherapy (LCCRT) a...
Detailed Description
In this trial, we will enroll patients in two cohorts: Cohort 1: A 6 patient safety lead-in for patients receiving capecitabine prior to beginning a randomized trial for the Long Course Chemo-radiati...
Eligibility Criteria
Inclusion
- Patients with pathologically confirmed locally advanced rectal adenocarcinoma who will be receiving total neoadjuvant therapy regimen with curative intent.
- AJCC stage II to III rectal adenocarcinoma that will require total neoadjuvant therapy.
- Adult, age \> or equal to 18 years (for Nebraska, age of consent is ≥19 years old)
- ECOG Performance Status 0-2
- Hemoglobin ≥ 9.0 g/dl, ANC ≥ 1,500 /dl, platelets ≥ 100,000 /dl (The use of transfusion or other intervention to achieve Hgb \> 9.0 g/dl is acceptable)
- Serum SGOT and bilirubin ≤ 1.5 times upper limit of normal
- Adequate renal function defined as follows:
- 1)Serum creatinine \< 1.5 mg/dl within 2 weeks prior to enrollment or 2)Creatinine clearance (CC) ≥ 50 ml/min within 2 weeks prior to enrollment determined by 24-hour collection or estimated by Cockcroft-Gault formula: CCr male = \[(140 - age) x (wt in kg)\]/\[(Serum Cr mg/dl) x (72)\], CCr female = 0.85 x (CrCl male) 8. Signed, written informed consent prior to completing any study specific procedures 9. Negative pregnancy test for women of child-bearing potential at the time of screening 10. Women of childbearing potential and male participants must agree to use two forms of a medically effective means of birth control throughout their participation in the treatment phase of the study and until 12 months following the last study treatment 11. Chest/Abdominal/Pelvic (CAP) CT/ pelvic MRI done within 8 weeks prior to randomization.
Exclusion
- Breast-feeding or pregnant
- Active infection requiring IV antibiotics 7 days before enrollment
- Prior, unrelated malignancy requiring current active treatment with the exception of cervical carcinoma in situ, basal cell or carcinoma of the skin, invasive cancers with a 5-year disease-free interval, resected cancer of the bladder or low-grade (Gleason 6 or less) prostate cancer
- Prior history of rectal adenocarcinoma (RAC)
- Prior history of pelvic radiotherapy for any other type of malignancy
- Known hypersensitivity or contraindication to any agent in FOLFOX or CAPOX regimen.
- Because corticosteroids are anti-inflammatory and could interrupt oxidative stress, patients will be excluded unless they are on stable or decreasing corticosteroids dose at the time of randomization.
- BMX-001 Specific Exclusion Criteria (Subjects meeting any of the following criteria are ineligible for study entry)
- Inadequately controlled hypertension (defined as systolic blood pressure \>150 mmHg and/or diastolic blood pressure \> 100 mmHg)
- Active or history of postural hypotension and autonomic dysfunction within the past year
- Known hypersensitivity to BMX-001
- Clinically significant (i.e. active) cardiovascular disease or cerebrovascular disease, for example cerebrovascular accidents ≤ 6 months prior to study enrollment, myocardial infarction ≤ 6 months prior to study enrollment, unstable angina, New York Heart Association (NYHA) Grade II or greater congestive heart failure (CHF), or serious cardiac arrhythmia uncontrolled by medication or potentially interfering with protocol treatment
- History or evidence upon physical/neurological examination of central nervous system disease (e.g. seizures) unrelated to cancer unless adequately controlled by medication or potentially interfering with protocol treatment
- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis) within 6 months prior to start of study treatment
- A marked baseline prolongation of QT/QTc interval (e.g., repeated demonstration of a QTc interval \>450 milliseconds (ms) (CTCAE grade 1) using the specific/usual choice by clinical center for correction factor.
- A history of additional risk factors for Torsades de Pointes (TdP) (e.g., congestive heart failure, hypokalemia, known family history of Long QT Syndrome).
- Note: Inclusion of Women and Minorities Both men and women and members of all races and ethnic groups are eligible for this trial.
Key Trial Info
Start Date :
August 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2029
Estimated Enrollment :
118 Patients enrolled
Trial Details
Trial ID
NCT05254327
Start Date
August 15 2022
End Date
June 1 2029
Last Update
August 7 2025
Active Locations (3)
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1
Markey Cancer Center
Lexington, Kentucky, United States, 40536
2
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
3
UT Health San Antonio MD Anderson Cancer Center
San Antonio, Texas, United States, 78229