Status:
UNKNOWN
Tissue Models for Liver Disease
Lead Sponsor:
University of Leicester
Collaborating Sponsors:
University Hospitals, Leicester
Conditions:
Liver Diseases
Eligibility:
All Genders
18+ years
Brief Summary
The human immune response to bacterial and viral local and systemic infection are fairly well understood, but we lack details on the earliest phases. Better knowledge of these events would be importan...
Detailed Description
This is a preclinical research project and no patient intervention is planned. The project makes use of anonymised human tissue samples discarded during radical surgery. The liver segment samples incl...
Eligibility Criteria
Inclusion
- The samples included in this project will be from patients undergoing elective surgery in the HPB Unit of the Leicester General Hospital.
- Liver segment samples from radical surgery are adult age (18-80 years)
- Presence of liver segment tissue in the discarded material after hepatopancreato-biliary surgery.
Exclusion
- The main exclusion criterion is acute invasive l infection, but these patients are automatically excluded from major surgery.
- Samples from patients treated with antibiotics prior to explant or surgery will not be excluded, but samples will have to be tested for residual antibiotic activity.
Key Trial Info
Start Date :
September 8 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05255042
Start Date
September 8 2021
End Date
December 31 2025
Last Update
October 25 2023
Active Locations (1)
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1
UHL NHS Trust - Leicester General Hospital
Leicester, United Kingdom, LE5 4PW