Status:
UNKNOWN
Nebulised Heparin in Patients With COVID-19 Pneumonia
Lead Sponsor:
Lady Reading Hospital, Pakistan
Conditions:
COVID-19 Pneumonia
Eligibility:
All Genders
18+ years
Phase:
PHASE2
PHASE3
Brief Summary
While the pandemic continues to incite panic and the guideline recommendations regarding management of COVID continue to change, we have growing evidence that ARDS secondary to Covid-19 is associated ...
Detailed Description
Second-year into the deadly COVID-19 pandemic and humanity continues to get affected/infected. The world has seen a total cases of 99.7 M, a death toll of 2.14 M, and counting4. To date, Pakistan has ...
Eligibility Criteria
Inclusion
- Age 18 year or older.
- Either gender
- Currently admitted to hospital.
- There is a PCR-positive sample for SARS-CoV-2 within the past 21 days. The sample can be a nasal or pharyngeal swab, sputum, tracheal aspirate, Broncho alveolar lavage, or another sample from the Patient
- WHO Modified ordinal clinical scale 3-5
Exclusion
- Intubated and on mechanical ventilation, or requiring immediate intubation as per the treating clinician's assessment
- Heparin allergy or heparin-induced thrombocytopenia
- APTT \>120 s, not due to anticoagulant therapy and does not correct with the administration of fresh frozen plasma
- Platelet count \<20 × 109 /L
- Pulmonary bleeding or uncontrolled bleeding
- Pregnant or might be pregnant
- Acute brain injury that may result in long-term disability
- Myopathy, spinal cord injury, or nerve injury or disease with a likely prolonged incapacity to breathe independently e.g. Guillain-Barre syndrome
- Treatment limitations in place (Ceiling of care), i.e. not for intubation, not for ICU admission
- Death is imminent or inevitable within 24 h
- Clinician objection
- Refusal to consent
Key Trial Info
Start Date :
June 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 20 2022
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05255848
Start Date
June 20 2022
End Date
October 20 2022
Last Update
April 26 2022
Active Locations (1)
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1
Pulmonology Department, Lady Reading Hospital, Peshawar
Peshawar, Khyber Pakhtunkhwa, Pakistan, 25000