Status:
COMPLETED
TPA in Acute Stroke With COVID Verus Non-COVID-19 Patients
Lead Sponsor:
Assiut University
Collaborating Sponsors:
Aswan University Hospital
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
The investigator will recruit consecutively all patients coming with acute ischemic stroke either with or without COVID -19 infection and suitable for IV injection with Tissue plasminogen activators a...
Detailed Description
Acute ischemic stroke (AIS) is a time sensitive medical emergency and a leading cause of morbidity and mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (IV alteplase) is ...
Eligibility Criteria
Inclusion
- Clinically diagnosed as acute ischemic stroke NIHSS\<25
- Symptoms onset less than 4.5 hours (3hours in diabetic or having a previous stroke) before beginning treatment.
Exclusion
- History of:
- A previous ischemic stroke or severe head trauma in previous 3 months.
- Previous intracranial hemorrhage .
- Intracranial neoplasm or gastrointestinal malignancy.
- Gastrointestinal hemorrhage in previous 3weeks.
- Intracranial or intra spinal surgery in previous 3months
- Clinically:
- Symptoms suggestive of subarachnoid hemorrhage.
- Persistent blood pressure elevation, systolic \> 185 or diastolic \>110 mmHg.
- Active internal bleeding.
- Presentations consistent with infective endocarditis.
- Stroke known or suspected to be associated with aortic arch dissection.
- Acute bleeding diathesis, including but not limited to conditions defined under hematologic.
- Hematologic:
- Platelet count \<100.000 \\ mm3
- Current anticoagulant use with INR\>1.7 or PT\>15sec or PTT\> 40sec.
- Therapeutic doses of low molecular weight received in 24 hours (not include the prophylactic doses).
- Head CT:
- Evidence of hemorrhage.
- Extensive regions of obvious hypo density
Key Trial Info
Start Date :
March 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 15 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05258565
Start Date
March 1 2022
End Date
September 15 2022
Last Update
October 31 2022
Active Locations (2)
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1
Aswan University Hospital
Aswān, Egypt
2
Assiut University Hospital
Asyut, Egypt