Status:
RECRUITING
The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
Lead Sponsor:
Boston Children's Hospital
Conditions:
Congenital Heart Disease
Eligibility:
All Genders
24-35 years
Phase:
NA
Brief Summary
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuro...
Detailed Description
Aim 1 is structured to determine the relationship between sulcal patterns(measured by MRI) and executive function in adults with d-TGA and if this relationship is modified by (a) presence of neuroresi...
Eligibility Criteria
Inclusion
- Persons who participated in the Boston circulatory arrest, pH and Hematocrit studies at Boston Childrens Hospital as children (n\~300).
- Normally-developed age- and sex-matched young adults who are able to provide informed consent to undergo the MRI portion of the study and limited neuropsychological evaluation (IQ assessment as well as neuropsychological tests for which normative references are not available).
Exclusion
- For controls - inability to complete the MRI (implanted metal, claustrophobia, personal history of mental illness, brain injury, prior brain intervention).
- Intellectual impairment precluding completion of the study questionnaires independently
- Unable to speak and read English fluently
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
225 Patients enrolled
Trial Details
Trial ID
NCT05258981
Start Date
July 1 2022
End Date
June 1 2026
Last Update
August 15 2023
Active Locations (1)
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1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115