Status:
UNKNOWN
Heart Rate Controller in Computed Tomography Coronary Angiography
Lead Sponsor:
Mahidol University
Conditions:
Heart Rate
Coronary Computed Tomography Angiography
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Coronary computed tomography angiography (CCTA) is one of important non-invasive test for diagnosis of coronary artery disease. Cardiac motion artifact by heart rate (HR) has impact on CCTA interpreta...
Detailed Description
Coronary computed tomography angiography (CCTA) is one of important non-invasive test for diagnosis coronary artery disease. Information of CCTA can provide information such as coronary artery lumen, ...
Eligibility Criteria
Inclusion
- Age of at least 18 year-old
- Received Coronary CT angiography at Siriraj Hospital to evaluate diagnosis of coronary artery disease or risk stratification of coronary artery disease
- Normal sinus rhythm with baseline HR \> 60 bpm which cardiac imaging specialist suggest using HR lowering intervention
Exclusion
- Atrial fibrillation
- Previous pacemaker implantation
- II- and III-degree atrio-ventricular-block
- NHYA class III - IV
- Documented LVEF \< 40%
- Contraindication for CCTA: Impaired renal function (serum creatinine \> 1.5 mg/dl), known allergy to iodinated contrast media, pregnancy, thyroid disease
- Blood pressure \< 100/70 mmHg
- Uncontrolled asthma and/or chronic obstructive pulmonary disease (defined as GOLD stage D) and/or uncontrolled reactive airway disease
- Current medication which cause severe interaction with calcium channel blocker, beta blocker and/or Ivabradine
- Known allergy to calcium channel blocker, beta blocker and/or Ivabradine
Key Trial Info
Start Date :
January 30 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2022
Estimated Enrollment :
246 Patients enrolled
Trial Details
Trial ID
NCT05261464
Start Date
January 30 2021
End Date
June 30 2022
Last Update
May 17 2022
Active Locations (1)
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1
Department of Internal Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University
Bangkok, Bangkoknoi, Thailand, 10700