Status:
COMPLETED
Aerobic Exercise Training in Patients With Chronic Hepatitis B and Hepatic Steatosis
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Copenhagen University Hospital, Hvidovre
Conditions:
Hepatitis B, Chronic
Hepatic Steatosis
Eligibility:
All Genders
30+ years
Phase:
NA
Brief Summary
This study is a randomised, controlled, unblinded, clinical intervention trial consisting of 12 weeks of aerobic exercise training. Thirty persons with chronic hepatitis B (CHB) and hepatic steatosis ...
Detailed Description
Primary aim: To investigate whether regular aerobic exercise training will decrease the fat-fraction of the liver in persons with CHB and hepatic steatosis shown by magnetic resonance imaging (MRI) by...
Eligibility Criteria
Inclusion
- Chronic hepatitis B defined by HBsAg positive \>6 months
- Positive HBV-DNA
- Age \>30
- Hepatic steatosis diagnosed by Controlled Attenuated Parameter (CAP) \>250 assessed by Transient Elastography or by ultrasound defined hepatic steatosis
Exclusion
- HIV, HCV, HDV-co infection
- Primary biliary cholangitis
- Wilsons Disease
- Autoimmune hepatitis
- Hepatocellular carcinoma
- Antiviral medication
- Steatogenic medication (systemic corticosteroids, amiodarone, tamoxifen, valproic acid, and methotrexate)
- Average alcohol intake \>30 g for men and \>20 g for women pr. day
- Contraindications for MRI scan
- Coronary artery disease contraindicating HIIT
- Unable to understand and read written information for participants written consent
- Pregnancy
Key Trial Info
Start Date :
March 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2023
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT05265026
Start Date
March 14 2022
End Date
October 1 2023
Last Update
October 27 2023
Active Locations (1)
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1
Centre for Physical Activity Research
Copenhagen, Denmark