Status:
RECRUITING
MRSA Decolonization in Complicated Carriage
Lead Sponsor:
Leiden University Medical Center
Conditions:
MRSA
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Multicenter open-label cluster randomized controlled trial determining the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRS...
Detailed Description
Rationale: MRSA decolonization has proven to prevent infection and reduce transmission. It has yet remained undecided which combination of anti-staphylococcal agents is most effective in the treatment...
Eligibility Criteria
Inclusion
- Age ≥18 years
- Complicated MRSA carriership. Complicated carriership is defined as having one of the following features: (i) the presence of MRSA located at another site than the nose, (ii) an active infection with MRSA, (iii) in vitro resistance for mupirocin, (iv) active skin lesions, (v) foreign material that connects an internal body site with the outside (e.g., urine catheter, external fixation material), (vi) previously failure of decolonization treatment.
- In case of none of the previously mentioned features, this is considered uncomplicated carriership.
- \- The ability to provide informed consent for the use of their data.
Exclusion
- \- Presence of any iv-access, urinary catheters or drains (because of high risk of treatment failure)
- Failure of previous decolonization attempt of complicated MRSA carriage
- Allergy or other contra-indication to either doxycycline, rifampicin or trimethoprim (these patients will participate in the observational arm)
- Previous participation in this study (every patient can only participate once)
- Pregnancy
Key Trial Info
Start Date :
July 25 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2028
Estimated Enrollment :
211 Patients enrolled
Trial Details
Trial ID
NCT05268120
Start Date
July 25 2022
End Date
May 1 2028
Last Update
March 6 2025
Active Locations (1)
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1
LUMC
Leiden, Netherlands