Status:
COMPLETED
Aronia and Cognitive Fitness
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Brain Vascular Function
Cognition
Eligibility:
All Genders
55-75 years
Phase:
NA
Brief Summary
Previously, beneficial effects of Aronia Melanocarpa extract (AME) supplementation on cognitive performance has been observed in healthy middle-aged adults. However, underlying mechanisms have not yet...
Eligibility Criteria
Inclusion
- Men and women, aged between 55-75 years
- BMI between 25-35 kg/m2
- Fasting plasma glucose \< 7.0 mmol/L
- Fasting serum total cholesterol \< 8.0 mmol/L
- Fasting serum triacylglycerol \< 4.5 mmol/L
- Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg
- Stable body weight (weight gain or loss \< 3 kg in the past three months)
- Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
- No difficult venipuncture as evidenced during the screening visit
Exclusion
- Smoking or smoking cessation \< 12 months
- Presence of diabetes mellitus
- Active cardiovascular disease like congestive heart failure or cardiovascular event
- Severe medical conditions, including asthma, chronic obstructive pulmonary disease (COPD), kidney failure, auto-inflammatory diseases or rheumatoid arthritis
- Unstable body weight (weight gain or loss \> 3 kg in the past three months)
- Use of dietary supplements or medication affecting the main outcomes of the study
- Use of an investigational product within another biomedical intervention trial within the previous month
- Contra-indications for MRI imaging (e.g., pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
- Left-handedness
- Familial hypercholesterolemia
- Abuse of drugs
- More than 3 alcoholic consumptions per day
- Use medication to treat blood pressure, lipid or glucose metabolism
Key Trial Info
Start Date :
June 8 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 25 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05268133
Start Date
June 8 2022
End Date
August 25 2023
Last Update
September 24 2025
Active Locations (1)
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1
Metabolic Research Unit Maastricht
Maastricht, Netherlands