Status:
COMPLETED
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Vascular Reactivity
Serum Biomarkers
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigaret...
Detailed Description
This work is an extension of prior funded work on the acute effects of nicotine free electronic cigarette aerosol on vascular function and inflammatory biomarkers in healthy non-smokers. Here, the inv...
Eligibility Criteria
Inclusion
- BMI: 18.5 to 30
- Current users of electronic cigarettes or tobacco cigarettes with a use history of six months or greater.
Exclusion
- Cancer
- HIV
- Mental illness in which the participant is not of proper cognizance
- Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic attacks)
- Serious arrhythmias
- Bronchospastic disease
- Upper respiratory tract infection within the past six weeks
- Medication affecting vascular function
- Antibiotics
- Magnetic resonance imaging contraindications (metallic implants/intraocular foreign bodies, claustrophobia, cardiac/cochlear implantable electronic devices, etc.)
Key Trial Info
Start Date :
June 7 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 28 2025
Estimated Enrollment :
55 Patients enrolled
Trial Details
Trial ID
NCT05271578
Start Date
June 7 2022
End Date
November 28 2025
Last Update
December 16 2025
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104