Status:
COMPLETED
Impact of Hypoxia on Resting and Exertional Right Ventricular Performance
Lead Sponsor:
University of Colorado, Denver
Conditions:
Ventricular Dysfunction, Right
Hypoxia
Eligibility:
All Genders
18-60 years
Brief Summary
The purpose of this study is to better understand how hypoxia (low oxygen) affects resting and exertional right ventricular function in healthy individuals.
Detailed Description
The right ventricle plays a critical role in exercise. As workload increases with exercise, the right ventricle augments contractility and lusitropy (diastolic relaxation) to accommodate increased ven...
Eligibility Criteria
Inclusion
- Age 18 - 60
- For women, premenopausal status
Exclusion
- Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension)
- Use of cardiac- or pulmonary-related medications
- Prior history of high altitude pulmonary edema or high altitude cerebral edema
- Body mass index \< 18.5 or \> 30
- Anemia
- Iron deficiency
- Iron supplementation (oral or intravenous) in the preceding 60 days
- Systemic anticoagulation or aspirin use that cannot be temporarily held for the study
- Pregnancy
- Non-cardiopulmonary disorders that adversely influence exercise ability (e.g. arthritis or peripheral vascular disease)
- Dedicated athletic training (defined here as spending \>9 hours per week in vigorous physical activity \[≥6 mets\])
- Regular high-altitude exercise (defined here as engaging in vigorous physical activity \[≥1 hour at ≥6 mets\] at ≥8,000 ft for \>2 days per week over the preceding 4 weeks)
- Residence at ≥8,000 ft for 3 or more consecutive nights in the preceding 30 days
Key Trial Info
Start Date :
April 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 15 2022
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05272514
Start Date
April 15 2022
End Date
December 15 2022
Last Update
May 9 2023
Active Locations (1)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045