Status:
ACTIVE_NOT_RECRUITING
Predictors of Cognitive Outcomes in Geriatric Depression
Lead Sponsor:
David Steffens
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Major Depressive Disorder
Neuroticism
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural a...
Detailed Description
In this renewal of R01MH108578, the investigators are seeking to extend findings from the initial study to focus on effects of stress in longitudinal mood and cognitive outcomes of late-life depressio...
Eligibility Criteria
Inclusion
- major depression, single episode or recurrent;
- ability to read and write English;
- Mini-Mental State Examination \>25.
Exclusion
- lifetime alcohol/drug dependence
- conditions associated with brain abnormalities such hydrocephalus, benign and cancerous brain tumors, epilepsy, Parkinson's disease, Huntington's chorea, dementia, demyelinating diseases, etc.
- untreated endocrine disorder other than diabetes mellitus
- established clinical diagnosis of dementia
- other primary psychiatric disorders, e.g., panic disorder, social phobia, obsessive- compulsive disorder, schizoaffective disorder, schizophrenia, bipolar disorder
Key Trial Info
Start Date :
September 28 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT05273996
Start Date
September 28 2021
End Date
June 30 2026
Last Update
July 10 2025
Active Locations (1)
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1
UConn Health
Farmington, Connecticut, United States, 06030