Status:
RECRUITING
Vascular Signature Mapping of Brain Tumor Genotypes
Lead Sponsor:
Leiden University Medical Center
Collaborating Sponsors:
Erasmus Medical Center
Conditions:
Glioma
Eligibility:
All Genders
18+ years
Brief Summary
A glioma is a primary brain tumor in adults that is characterized by a highly variable, but overall poor survival. The optimal timing of treatment is in part determined by the expected biological beha...
Detailed Description
Objective of the study: The primary objective is to develop and clinically validate a fast multi-parametric MRI acquisition technique, for non-invasive and comprehensive characterization of the tumor...
Eligibility Criteria
Inclusion
- Patients scheduled for brain MRI with contrast injection as part of the clinical diagnostic procedure (cohort 1)
- Patients diagnosed with suspected glioma scheduled for brain MRI as part of the clinical diagnostic procedure (cohort 2)
- Patients with (suspected) glioma referred for tumor biopsy or resection (cohort 3)
- Age ≥ 18 years (all cohorts)
- Signed informed consent (all cohorts)
Exclusion
- Subjects with contra-indications for an MRI exam
- Subjects with reduced kidney function because of the risk on developing nephrogenic systemic fibrosis (NSF) under gadolinium-based contrast injection
- Subjects with pregnancy
- Subjects undergoing a clinical protocol that requires scanning during CA injection (cohort 1)
Key Trial Info
Start Date :
August 16 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2026
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT05274919
Start Date
August 16 2022
End Date
March 31 2026
Last Update
March 10 2025
Active Locations (2)
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1
Leiden University Medical Center
Leiden, Netherlands, 2333ZA
2
Erasmus University Medical Center
Rotterdam, Netherlands, 3000CA