Status:
ACTIVE_NOT_RECRUITING
Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy
Lead Sponsor:
Ohio State University
Conditions:
Suicide
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The current study is a clinical trial, meaning a research study in which human subjects are prospectively assigned to one or more interventions to evaluate the effects of those interventions on health...
Eligibility Criteria
Inclusion
- Generally medically and neurologically healthy
- Age 18 years or older at the time of consent
- Willing and able to give informed consent
- Individuals in the acutely suicidal group: endorse current suicide intent as indicated by a total score of 5 or greater on the Beck's Scale for Suicidal Ideation.
Exclusion
- Medical or neurologic condition or neurocognitive dysfunction that would interfere with the study
- Current or past manic/hypomanic episode, schizophrenia, or psychotic symptoms
- Deafness in either ear
- Currently pregnant or trying to become pregnant
- Electroconvulsive therapy (ECT) within the past 6 months
- Current moderate to severe substance use disorder
- Lack of fluency in English
- Positive alcohol breathalyzer test and/or acute drug intoxication the day of the fMRI scans
- Unwilling or unable to sign the informed consent document
- Under 18 years old at the time of enrollment
- Traumatic brain injury from a suicide attempt or another event
- Presence of ferrous-containing metals within the body
- Inability to tolerate small, enclosed spaces without significant anxiety
- Individuals enrolled as controls: no lifetime history of any DSM-5 disorder
- Individuals enrolled as controls: no lifetime history of suicide ideation or intent
Key Trial Info
Start Date :
July 28 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2026
Estimated Enrollment :
191 Patients enrolled
Trial Details
Trial ID
NCT05275101
Start Date
July 28 2021
End Date
February 28 2026
Last Update
August 6 2025
Active Locations (1)
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1
Ohio State University
Columbus, Ohio, United States, 43210