Status:
COMPLETED
Impact of Periodontal Treatment on Local miRNA Expression
Lead Sponsor:
University of Catania
Conditions:
Cardiovascular Diseases
Periodontal Diseases
Eligibility:
All Genders
18-70 years
Brief Summary
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 12...
Detailed Description
The patients selected for the study were divided into 2 groups: group 1 (FM-SRP), group 2 (Q-SRP). Any selected subject underwent anamnestic and periodontal examination, blood and GCF sampling. MiRNA ...
Eligibility Criteria
Inclusion
- Presence of at least 15 teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
March 14 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 20 2022
Estimated Enrollment :
89 Patients enrolled
Trial Details
Trial ID
NCT05275127
Start Date
March 14 2022
End Date
November 20 2022
Last Update
April 7 2023
Active Locations (1)
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1
University of Catania
Catania, CT, Italy, 95124