Status:
UNKNOWN
Lactobacillus Reuteri for Non-surgical Periodontal Treatment of Chronic Periodontitis With Type 2 Diabetes Patients
Lead Sponsor:
The Dental Hospital of Zhejiang University School of Medicine
Conditions:
Periodontitis
Eligibility:
All Genders
35-70 years
Phase:
NA
Brief Summary
This study aims to investigate the clinical and microbiological efficacy of Lactobacillus reuteri as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis with type 2 di...
Detailed Description
Periodontitis and diabetes affect the course and outcome of each other. Many studies have shown that for patients with periodontitis, concomitant diabetes can aggravate the destruction of periodontal ...
Eligibility Criteria
Inclusion
- age between 35 to 70 years,
- type 2 diabetes with treatment ≥ 6-month, with HbA1c≤7.5%,
- generalized periodontitis (Stage III or IV),
- no less than 15 teeth
Exclusion
- smoking, or quit smoking for less than 5 years;
- Suffering from other known systemic diseases that can affect the progression of periodontitis (immune abnormalities, osteoporosis, history of head and neck radiotherapy, etc.);
- Received periodontal treatment within 6 months;
- Have taken antibiotics, non-steroidal anti-inflammatory drugs, immunosuppressants, hormones and other drugs that affect periodontal within 3 months;
- Have taken probiotics within 6 months;
- Prophylactic use of antibiotics is required;
- Pregnant and lactating women;
Key Trial Info
Start Date :
June 8 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 20 2024
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT05275803
Start Date
June 8 2023
End Date
May 20 2024
Last Update
June 7 2023
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