Status:
COMPLETED
Study Comparing Treatment With Alluzience vs Reconstituted Toxin
Lead Sponsor:
Galderma R&D
Conditions:
Glabellar Frown Lines
Eligibility:
FEMALE
18-65 years
Phase:
PHASE4
Brief Summary
This is a Phase IV, open-label, randomized, interventional, two-armed, multi-centre study to investigate subject treatment perception and Investigator treatment experience when using Alluzience or vac...
Detailed Description
This is a Phase IV, open-label, randomized, interventional, two-armed, multi-centre study to investigate subject treatment perception and Investigator treatment experience when using Alluzience or vac...
Eligibility Criteria
Inclusion
- Female 18 to \< 65 years of age.
- Moderate to severe GL at maximum frown as assessed by the Investigator.
- Female of non-childbearing potential (i.e., postmenopausal \[absence of menstrual bleeding for 1 year prior to screening, without any other medical reason\], or has undergone hysterectomy or bilateral oophorectomy). OR Female of childbearing potential with a negative urine pregnancy test at screening and baseline, and agrees to use a highly effective and approved contraceptive method for the duration of the study.
- Time and ability to complete the study and comply with instructions.
- Understands the study requirements and signed the informed consent form (ICF).
- Subjects who have planned to undergo aesthetic facial treatment with powder toxin at the study site.
- Previous use of any approved botulinum toxin in facial areas.
Exclusion
- Previous use of any botulinum toxin in facial area within 6 months prior to study treatment.
- Female who is pregnant, breast feeding, or intends to conceive a child during the study.
- Known allergy or hypersensitivity to any component of the study product or any botulinum toxin serotype.
- Any known contraindication such as subject with bleeding disorder or subject currently using anticoagulants.
- Previous use of any hyaluronic acid soft tissue augmentation therapy in the treated area within 3 months before baseline.
- Previous soft tissue augmentation with any permanent (non-biodegradable such as silicone, polyacrylamide, etc) or semi-permanent (i.e., calcium hydroxylapatite, poly-L-Lactic acid or polymethyl-methacrylate) product; lifting threads, or autologous fat in the treatment area.
- Subject has any prior or current psychiatric illness (e.g. Psychosis, depression, anxiety), alcohol or drug abuse, or is taking antidepressant, anxiolytic, or antipsychotic medication that, in the Investigator's opinion, could affect the subject's safety and/or participation in the study.
- Other concurrent medical conditions, therapy, or other condition that, in the Investigator's opinion, would interfere with the evaluation of the study medication, safety or efficacy, and/or put the subject at risk if he/she participates in the study.
- Participation in an investigational device or drug study within 30 days prior to study treatment or plans to enroll in any other investigational study during participation in this study.
- Study site personnel, close relatives of the study site personnel (e.g. parents, children, siblings, or spouse), employees or close relatives of employees at the Sponsor company.
Key Trial Info
Start Date :
February 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 12 2022
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05277337
Start Date
February 4 2022
End Date
October 12 2022
Last Update
February 16 2024
Active Locations (8)
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1
Galderma Research Site 2003
Bochum, Germany, 44791
2
Galderma Research Site 2001
Düsseldorf, Germany, 40212
3
Galderma Research Site 2002
Düsseldorf, Germany, 40545
4
Galderma Research Site 1003
Edinburgh, United Kingdom, EH10 4BE