Status:
COMPLETED
EARLY Assessment of MYOcardial Tissue Characteristics in OBESITY (EARLY-MYO-OBESITY)
Lead Sponsor:
RenJi Hospital
Collaborating Sponsors:
Ningbo Hangzhou Bay Hospital
Shanghai Jiading Central Hospital
Conditions:
Obese
Eligibility:
All Genders
18-75 years
Brief Summary
EARLY-MYO-OBESITY-CMR is a prospective, three-center, cardiac imaging study to investigate cardiac morphology, function, and tissue phenotypes in a cohort of non-diabetic obese adults, and compare wit...
Detailed Description
1. Transthoracic echocardiography was performed to analyze the LV morphology and function. 2. CMR was performed within 24 hours of the echocardiographic examination to assess the cardiac morphology , ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- age 18-75 years without cardiac symptoms or known cardiac diseas;
- body mass index ≥25 kg/m2
- Exclusion criteria:
- coronary artery disease (coronary artery stenosis \>50% on angiography or coronary computed tomography, documented myocardial infarction, or a history of coronary artery bypass graft surgery or percutaneous coronary intervention)
- non-ischemic cardiovascular disease, such as idiopathic cardiomyopathy, valvular disease, congenital heart disease, or pulmonary heart diseas
- a left ventricular (LV) ejection fraction of\<50% on echocardiography or a history of heart failure
- arrhythmia or the presence of bundle branch block on electrocardiography
- pacemaker or defibrillator implantation
- renal dysfunction with an estimated glomerular filtration rate of \<60 mL/min/1.73 m2
- contraindications to cardiac magnetic resonance (CMR) imaging
- malignancy or life expectancy of less than 2 year
- inability to provide written informed consent
Exclusion
Key Trial Info
Start Date :
January 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05277779
Start Date
January 1 2019
End Date
December 30 2022
Last Update
June 1 2023
Active Locations (1)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127