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Status:

RECRUITING

Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

Lead Sponsor:

University of Turku

Collaborating Sponsors:

Turku University Hospital

Hospital District of Helsinki and Uusimaa

Conditions:

Osteoarthritis, Hip

Rheumatoid Arthritis

Eligibility:

All Genders

18-74 years

Brief Summary

The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.

Detailed Description

The specific objectives of this project are: 1. Using the latest single-cell RNA sequencing (scRNAseq) techniques the investigators aim to A) characterize what kind of cell populations are found in d...

Eligibility Criteria

Inclusion

  • Inclusion Criteria for the main (OA) study:
  • Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.
  • Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.
  • \----
  • Inclusion Criteria for the Rheumatoid sub-study:
  • Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.
  • \----
  • Exclusion Criteria:
  • The body mass index must be below 35
  • Age \< 18 or \> 74
  • The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.
  • For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.

Exclusion

    Key Trial Info

    Start Date :

    January 11 2023

    Trial Type :

    OBSERVATIONAL

    Allocation :

    ESTIMATED

    End Date :

    December 1 2028

    Estimated Enrollment :

    110 Patients enrolled

    Trial Details

    Trial ID

    NCT05278520

    Start Date

    January 11 2023

    End Date

    December 1 2028

    Last Update

    August 24 2025

    Active Locations (4)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 1 (4 locations)

    1

    PET-centre, University of Turku

    Turku, Southwest Finland, Finland

    2

    Turku Bioscience, University of Turku

    Turku, Southwest Finland, Finland

    3

    Turku University Hospital

    Turku, Southwest Finland, Finland

    4

    Helsinki University Hospital

    Espoo, Uusimaa, Finland