Status:
UNKNOWN
a Safety and Tolerability Study of EP-9001A in Healthy Volunteers
Lead Sponsor:
Chengdu Easton Biopharmaceuticals Co,Ltd
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
Nerve Growth Factor（NGF）plays an important role in the pathogenesis of neuropathic pain including cancer pain. EP-9001A is a humanized monoclonal antibody targeting NGF, thus thought to alleviate neur...
Detailed Description
Nerve Growth Factor（NGF）plays an important role in the pathogenesis of neuropathic pain including cancer pain. EP-9001A is a humanized monoclonal antibody targeting NGF, thus thought to alleviate neur...
Eligibility Criteria
Inclusion
- Healthy male or female Chinese volunteers ≥18 and ≤45 years of age at the screening visit;
- Body weight ≥ 45.0 kg for female subjects and ≥ 50.0 kg for male subjects with a body mass index (BMI) between 19.0 and 26.0 kg/m2( including border value);
- Subjects during the trial (female subjects from 14 days before dosing, male subjects from dosing) to 3 months after the end of the trial without fertility or sperm/egg donation plan and voluntarily take effective physical contraception measures;
- According to the results of physical examination, vital signs, ECG and clinical laboratory tests during the screening period, all the test results are normal or abnormal without clinical significance as judged by the investigator;
- Signed a written informed consent.
Exclusion
- history of allergic diseases (including but not limited to asthma, urticaria, allergic rhinitis), or a history of drug allergy, or a history of allergy to the test drug ingredients;
- history of clinical serious diseases and not cured, such as motor (muscle and bone) system, digestive system, respiratory system, genitourinary system, blood (hematopoietic) system, circulatory system, nervous system, mental system, endocrine system, cardiovascular system and metabolic abnormalities;
- received surgery in the past 3 months or have surgery plan during the trial ;
- Have used any prescription, over-the-counter or health care products in the past 2 weeks;
- took more than 10 cigarettes a day or the same amount of tobacco or can not stop tobacco during trial;
- alcohol breath test positive;
- History of alcohol abuse within the past 6 months;
- History of drug abuse, positive results of urine multiple drug tests;
- Drink excessive tea, grapefruit juice, coffee or caffeinated beverages (an average of more than 8 cups per day, 200 mL per cup) every day in the past 1 month;
- Participated in other drug clinical trials in the past 3 months, or plan to participate in other clinical trials during this study;
- Blood loss/blood donation of more than 400 mL in the past 3 months (except for female physiological blood loss), or receiving blood transfusion or use of blood products, or planning to donate blood during the trial or within 1 month after the end of the trial;
- Vaccinated within the past 1 month
- positive in Hepatitis B surface antigen, hepatitis C antibody, human immunodeficiency virus antibody, syphilis specific antibody screening;
- Subjects who are lactating, pregnant or plan to become pregnant or conceive recently;
- Patients with a history of bone or joint diseases, including but not limited to osteoarthritis, pathological fractures, osteonecrosis, rheumatoid arthritis, neuropathic arthritis, lupus erythematosus or inflammatory joint diseases;
- Patients with a history of joint-related events, such as total joint replacement (TJR) surgery, meniscus or knee ligament injury (with or without surgical repair) or joint infection, or bone dislocation, hip dislocation, knee dislocation within 1 year before screening;
- Kellgren-Lawrence grade ≥ 2 in any major joint (shoulder, hip, knee);
- History of clinically significant peripheral neuropathy, paresthesia, dysesthesia;
- History of autonomic neuropathy or diabetic neuropathy;
- The investigator assesses the poor compliance, or the investigator believes that the subject has any other conditions that are not suitable for participating in this clinical study
Key Trial Info
Start Date :
March 23 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT05278611
Start Date
March 23 2022
End Date
December 1 2022
Last Update
April 4 2022
Active Locations (1)
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1
West China Hospital，Sichuan University
Chengdu, Sichuan, China