Status:
COMPLETED
Adipose-tissue-derived Total-Stromal-cells (TOST) Therapy in Knee Osteoarthritis
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Collaborating Sponsors:
Dhaka Medical College
Conditions:
Osteoarthritis Knees
Eligibility:
All Genders
40-80 years
Phase:
PHASE2
Brief Summary
In this phase II Randomized Clinical Trial (RCT), impacts of a single Intra-articular injection of autologous adipose tissue derive total-stromal-cells (TOST) on knee pain, physical function, stiffnes...
Detailed Description
A phase II randomized clinical trial (RCT) was performed with primary Knee osteoarthritis (KOA) attended in the department of physical medicine and rehabilitation, BSMMU, between January 2018 and Dece...
Eligibility Criteria
Inclusion
- Primary KOA with KL-grade II and III radiological changes
Exclusion
- KOA received IA steroid, viscosupplementation, or PRP injection or undergone knee surgery within the last six months.
- Patients with septic and tubercular arthritis, post-traumatic hemarthrosis, unstable knee joint due to anterior cruciate ligament (ACL) injury, malignancy, autoinflammatory arthritis (gout), inflammatory disease (rheumatoid arthritis, psoriatic arthritis, reactive, and ankylosing spondylitis), and charcot arthropathy.
- Patients with local eczematous skin and skin infection
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05280002
Start Date
January 1 2018
End Date
December 31 2021
Last Update
March 15 2022
Active Locations (1)
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1
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh