Status:
UNKNOWN
Prevention and Treatment of Reperfusion Injury After Mechanical Thrombectomy in Acute Ischemic Stroke
Lead Sponsor:
Xijing Hospital
Conditions:
Stroke Patients
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Ischemic stroke accounts for 80% of all strokes and there is a lack of effective treatment options.Mechanical thrombectomy can significantly improve the vascular recanalization rate and reduce the dis...
Eligibility Criteria
Inclusion
- Patients with acute cerebral infarction with large vessel occlusion within 24 hours of onset .(internal carotid artery, M1 or M2 segment of middle cerebral artery, A1 segment of anterior cerebral artery).
- 18 years≤age≤85 years.
- CT ruled out cerebral hemorrhage and subarachnoid hemorrhage.
- Informed consent signed by patient or legal representative.
- Successful vascular recanalization (defined as modified thrombolysis in cerebral infarction (mTICI)≥2b/3 for cerebral infarction with anterior bleeding).
- Degree of disease: 6 points≤NIHSS ≤19 points.
Exclusion
- Preoperative or immediate postoperative CT showed active bleeding or was known to have significant bleeding tendency \[International Normalized Ratio(INR)\>3.0,Platelet count \<30×10 9/L.
- Severe heart, liver and kidney insufficiency.
- Blood glucose \<2.7mmol/L or \>22.2mmol/L.
- Severe hyperemia beyond medication control (\>180/105mm Hg).
- Patients with Alberta early stroke grading CT scores (ASPECT)\<6.
- Patients with a life expectancy of less than 90 days.
- Blood pressure is below 90/60 mm Hg.
- mRS≥3 points .
- pregnant women.
Key Trial Info
Start Date :
September 22 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05282290
Start Date
September 22 2022
End Date
May 1 2024
Last Update
December 29 2022
Active Locations (1)
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1
XiJing hospital
Xi'an, Shaanxi, China, 710000