Status:
COMPLETED
Efficacy of tACS for Treatment of Auditory Hallucinations in Refractory Schizophrenia
Lead Sponsor:
Tianjin Anding Hospital
Conditions:
Schizophrenia
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the feasibility and efficacy of transcranial alternating current stimulation (tACS) as an add-on treatment for auditory hallucinations in refractory schizophrenia....
Detailed Description
This is a randomized, double-blind, sham-controlled study to detect the effect of tACS for treatment of refractory auditory hallucinations in schizophrenia. 50 participants were randomly assigned 1:1 ...
Eligibility Criteria
Inclusion
- Eligible participants aged 18-70 with DSM-5-defined schizophrenia or schizophrenia-like disorder.
- Duration of illness \> 12 weeks.
- Being clinically stable and on an adequate therapeutic dose of antipsychotics for at least 8 weeks prior to enrolment.
- Junior high school education or above
- After treatment with ≥ 2 different antipsychotics (greater than the equivalent dose of chlorpromazine 600mg), the curative effect was poor (CGI ≥ 4 points or the PANSS score reduction rate since this treatment was less than 20%)
- Agreement to participate in the study and provide the written informed consent.
Exclusion
- Having unstable medical conditions, current psychiatric comorbidity or active substance use disorder (in exception to caffeine and/or tobacco)
- Having Serious physical diseases or nervous system diseases;
- Having any brain device / implant, including cochlear implant and aneurysm clip;
- Having a history or family history of autoimmune diseases or immune diseases;
- Pregnancy or breastfeeding at enrollment;
- Skin lesions on scalp at the area of electrode application.
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 21 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05282329
Start Date
September 1 2020
End Date
September 21 2022
Last Update
October 7 2022
Active Locations (1)
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1
Tianjin Anding Hospital
Tianjin, Tianjin Municipality, China