Status:
RECRUITING
Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
Department of Nephrology, Odense University Hospital
Department of Clinical Genetics, Odense University Hospital
Conditions:
Contrast-induced Nephropathy
Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The use of contrast media (CM) poses a risk of post-contrast acute kidney injury (PC-AKI), especially among patients chronic kidney disease (CKD). International guidelines recommend intravenous (IV) h...
Detailed Description
Trial design: This study is a pragmatic investigator-iniated, single-centre, open-labelled, parallel-group non-inferiority randomized controlled trial with two parallel arms. Patients will randomly b...
Eligibility Criteria
Inclusion
- eGFR \< 30 mL/min/1.73 m2
- Scheduled for elective IV CECT
- Age ≥ 18
- Signed informed consent
Exclusion
- Allergy to Iodine
- Pregnancy
- Active dialysis treatment
- Acute infectious or inflammatory disease
- Acute pre- and/or post-renal kidney failure
- Unable to understand study information
Key Trial Info
Start Date :
April 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
254 Patients enrolled
Trial Details
Trial ID
NCT05283512
Start Date
April 20 2022
End Date
December 31 2027
Last Update
August 1 2025
Active Locations (1)
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1
Department of Cardiology
Odense C, Fyn, Denmark, 5000