Status:
COMPLETED
Reducing Nocebo Effects on Pressure Pain
Lead Sponsor:
Leiden University
Conditions:
Pain
Hyperalgesia
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
Nocebo effects are known to adversely affect the experience of various physical symptoms, such as pain and itch. Nocebo effects can be induced by associative learning mechanisms of classical condition...
Detailed Description
The primary objective of the study is to investigate whether open- and closed-label counterconditioning are more effective in reducing nocebo effects than extinction. The experimental (open- and clos...
Eligibility Criteria
Inclusion
- Aged 18-35 years
- Good understanding of written and spoken Dutch or English
Exclusion
- Severe somatic or psychiatric morbidity (e.g., heart/lung diseases, DSM-V psychiatric disorders)
- Raynaud's disease, chronic pain complaints at present or in the past
- Current pain complaints (\> 2 on NRS)
- Current use of medication (except for birth-control pill)
- Injuries on the non-dominant hand
- Refusal/inability to remove nail polish or artificial nails for the experiment
- Pregnancy or breastfeeding
Key Trial Info
Start Date :
March 23 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 5 2022
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT05284383
Start Date
March 23 2021
End Date
April 5 2022
Last Update
August 25 2022
Active Locations (1)
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1
Leiden University
Leiden, Netherlands, 2333AK