Status:
UNKNOWN
Central China Rosai-Dorfman Disease Registry
Lead Sponsor:
Tongji Hospital
Conditions:
Rosai-Dorfman Disease
Langerhans Cell Histiocytosis
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
This is a research study among patients with Rosai-Dorfman disease.
Detailed Description
Rosai-Dorfman disease is a rare disorder characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadeno...
Eligibility Criteria
Inclusion
- Diagnosis of a histiocytic disorder as determined by a corroborating constellation of histopathology, clinical, and/or radiologic findings. All participants will undergo Standard of Care MRA, CTA or imaging examination.
Exclusion
- Known intracranial involvement of histiocytosis (including dura, leptomeninges and brain parenchyma) Prior stroke or intracranial hemorrhage Other (non-histiocytic) intracranial neoplasm or neurological disorder deemed by the PI or Co-PI to confound neuroimaging studies (e.g., demyelinating disease) Existing diagnosis of a psychiatric disorder or untreated mood disturbance Existing diagnosis of a neurodegenerative disease, such as Alzheimer's disease Chronic or daily excessive alcohol consumption as determined by the PI. History of chronic use of corticosteroids, defined as continuous treatment for six months or longer at any time in the past History of severe claustrophobia or other contraindications to patient SOC brain MRI Prior intravenous cytarabine or cladribine Other current or prior treatments (e.g., high-dose chemotherapy for a different cancer) deemed by the PI or Co-PI to confound imaging studies or cognitive performance
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05284942
Start Date
October 1 2011
End Date
June 1 2022
Last Update
March 17 2022
Active Locations (2)
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1
Tongji Hospital
Wuhan, Hubei, China, 430030
2
Tongji Hospital
Wuhan, Hubei, China, 430030