Status:
UNKNOWN
Periodontal Regeneration Using Vitamin A and PRF Compared to PRF Alone Treating Intra-bony Defects
Lead Sponsor:
Cairo University
Conditions:
Intrabony Periodontal Defect
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
Will the addition of vitamin A (Retinol) to PRF add more periodontal regenerative value in the treatment of intra-bony defects compared to PRF alone, clinically?
Detailed Description
Vitamin A has been extensively studied for its role in bone health. Vitamin A can be consumed in two forms, i.e., preformed retinol and pro-vitamin A. Preformed retinol is often found in food originat...
Eligibility Criteria
Inclusion
- Stage III periodontitis patient (Papapanou et al., 2018) with 3 walled or 2 walled intra-bony defects.
- Non-smokers
- No pregnancy
- Medically free
- Presence of intra-bony defect of three or two walls (as predominant component) with a radiographic intra-bony component of ≥3 mm;
- Presence of ≥2 mm of keratinized gingiva at the tooth with the defect.
- Willingness to optimal compliance with the study procedures
Exclusion
- Uncontrolled systemic or local infection in the tissue of interest,
- History or clinical evidence or positive tests for Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV).
- History of chronic autoimmune disease
- Participation in an intervention trial in the same quadrant in the previous two months.
- Type III tooth mobility, vertical root fracture in the selected tooth.
- Contraindications for periodontal surgery.
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT05285293
Start Date
June 1 2022
End Date
December 1 2023
Last Update
March 17 2022
Active Locations (1)
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1
Cairo University
Cairo, Egypt