Status:
WITHDRAWN
Standard of Care Lifestyle Support for Stage III NSCLC Patients
Lead Sponsor:
Maastricht Radiation Oncology
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Brief Summary
Offering an early-initiated supportive care program to stage III NSCLC patients to prevent deterioration of performance status and increase compliance of patients that complete chemoradiation as well ...
Detailed Description
In inoperable Stage III Non-Small Cell Lung Cancer (NSCLC), consolidation immune checkpoint inhibition with the PD-L1 inhibitor durvalumab, given within 6 weeks after completion of concurrent platinum...
Eligibility Criteria
Inclusion
- Pathological diagnosis of adequately staged (according to standard practice using chest-CT, FDG-PET, brain imaging MRI/CT) NSCLC
- Participant is willing and able to give informed consent for participation in the trial
- Aged 18 years or above
- Scheduled to receive one of the following two therapeutic strategies:
- Concurrent chemotherapy and radiotherapy with photons (60 Gy in 30 fractions of 2 Gy) followed by durvalumab in patients with stage III NSCLC
- Concurrent chemotherapy and radiotherapy with protons (60 Gy in 30 fractions of 2 Gy) followed by durvalumab in patients with stage III NSCLC
- Able and willing to comply with all trial requirements
Exclusion
- Mixed non-small cell lung cancer with other histology such as small cell lung cancer
- Not able to comply with the study protocol
- Less than 18 years old
- Pregnancy or not able to comply with adequate contraception in women with child baring potential
- Previous radiotherapy to the chest for benign or malignant conditions, including radiation for breast cancer
- Previous malignancy treated with chemotherapy, immune therapy or radiotherapy (irrespective of when this happened)
- Previous malignancies treated with surgery only are allowed if 2 years or more before inclusion in the present study
Key Trial Info
Start Date :
August 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2025
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT05287971
Start Date
August 1 2023
End Date
May 1 2025
Last Update
September 6 2023
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