Status:
COMPLETED
Propofol or Sevoflurane Anesthesia in Egyptian Patients
Lead Sponsor:
Rehab Werida
Conditions:
Anesthesia
Eligibility:
All Genders
21-75 years
Phase:
NA
Brief Summary
The proposed research in this application will investigate postoperative cognitive function, pain index, inflammatory response, and oxidative stress effects of propofol versus sevoflurane anesthetic d...
Detailed Description
1. Ethical committee approval will be obtained from Ethics committee of Faculty of Pharmacy, Damanhour University. 2. Ethical committee approval will be obtained from Ethics committee of General Organ...
Eligibility Criteria
Inclusion
- Patients who will be candidates for elective, major, non-cardiac abdominal operations under general anesthesia with propofol or sevoflurane.
- Patients aged from 21 and older, of either sex.
- Patients with body mass index (BMI) 25 to 35 kg/m².
- Patients belong to the American Society of Anesthesiologist (ASA) physical status I or II.
- Patients should have basically normal preoperative laboratory investigations.
Exclusion
- Patients with mini-mental state examination (MMSE) score \<24 points.
- Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases.
- Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia.
- Patients who are on long-term use of sedatives or steroids.
- Alcohol or drug abuse.
- Allergy to any drug will be used in this study.
Key Trial Info
Start Date :
December 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2023
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT05289349
Start Date
December 1 2021
End Date
April 1 2023
Last Update
June 4 2024
Active Locations (1)
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1
Damanhour Teaching Hospital, General Organization for Teaching Hospitals and Institutes.
Damanhūr, Elbehairah, Egypt, 31527