Status:
ACTIVE_NOT_RECRUITING
Evaluating Prenatal Exome Sequencing Study
Lead Sponsor:
Leiden University Medical Center
Conditions:
Congenital Anomalies
Mendelian Disorders
Eligibility:
All Genders
18+ years
Brief Summary
This study evaluates the impact of the various outcomes of pES (definitive diagnosis, probable diagnosis and IF) on clinical decision making and on parental psychological wellbeing, compared between d...
Detailed Description
Foetal anomalies as detected on prenatal ultrasound are present in 2-3% of pregnancies. The diagnosis of a genetic syndrome as the underlying cause often has significant consequences for the prognosis...
Eligibility Criteria
Inclusion
- At least one fetal anomaly detected in the current pregnancy, irrespective of gestational age;
- Pregnancy ongoing;
- Mother at least 18 years old and providing consent for pES;
- If father is available: father at least 18 years old and providing consent for pES.
Exclusion
- There are no exclusion criteria.
Key Trial Info
Start Date :
February 21 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2026
Estimated Enrollment :
235 Patients enrolled
Trial Details
Trial ID
NCT05290701
Start Date
February 21 2022
End Date
October 1 2026
Last Update
March 6 2025
Active Locations (1)
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1
Leiden University Medical Centre
Leiden, South Holland, Netherlands, 2333ZA