Status:
UNKNOWN
Efficacy of Pregabalin Vs Duloxetine in Diabetic Peripheral Neuropathic Pain at Variable Dose
Lead Sponsor:
Aga Khan University
Conditions:
Diabetic Peripheral Neuropathic Pain
Eligibility:
All Genders
18-70 years
Phase:
EARLY_PHASE1
Brief Summary
Background Diabetic neuropathy is a widespread, debilitating condition and its management needs a significant cost. Around, 50% of diabetes mellitus (DM) patients suffer from Diabetic Peripheral Neuro...
Detailed Description
This is prospective clinical research, that will be executed from Feb 2022 to May 2022, including, only those patients who are diagnosed with DPNP of at least six months duration, attending Rehman Med...
Eligibility Criteria
Inclusion
- Both male and female patient with age more than 18 years to 70 years.
- Patients diagnosed with peripheral neuropathic pain affected by diabetes from at least 24 weeks and all other causes off peripheral painful neuropathy has been already excluded by their primary physician.
- Patients who may agree with written inform consent.
- HbA1c ≥ 6.5% and ≤ 10%
Exclusion
- Patients with severe hepatic disease, cardiovascular diseases, Epilepsy and respiratory diseases or any other medical or psychiatric disorders.
- Patients with uncontrolled hypertension.
- DM patients with foot ulcers, foot injuries or any other painful lesion.
- Patients who are already using or used duloxetine or pregabalin in last three month.
- Pregnant women or those who may not agree to use medical recommended birth control procedures during the treatment.
- Patient with thyroid known disorders or diagnosed during the screening
- Vitamin B12 deficient patient
- Chronic alcoholics
- DKD, with eGFR \< 30ml/min
- Hypertriglycedmia (TGs more then 250mg/dl)
Key Trial Info
Start Date :
October 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT05292066
Start Date
October 1 2022
End Date
December 1 2022
Last Update
August 4 2022
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