Status:
UNKNOWN
Cognitive Function and Brain Connectivity in CAS Patients:a Rs-fMRI Study
Lead Sponsor:
First Affiliated Hospital of Zhejiang University
Conditions:
MRI, Functional
Carotid Artery Stenosis
Eligibility:
All Genders
55-80 years
Brief Summary
This is a prospective study aimed to explore the changes of cognitive function after surgery for CAS and the correlation with brain connectivity, in order to look for the clinical biomarkers to predic...
Detailed Description
Carotid artery stenting (CAS) can significantly decrease the incidence of ischemic stroke in patients with severe carotid artery stenosis has been confirmed in large randomized controlled studies (1, ...
Eligibility Criteria
Inclusion
- age between 55 years and 80 years
- unilateral internal carotid artery stenotic degree ≥ 70%
- right-hand-dominant
- free of stroke, TIA, dementia, and depression
- modified Rankin Scale: 0 or 1
- education ≥6 years
- obtained written informed consent.
Exclusion
- contralateral internal carotid artery stenosis ≥ 50%
- posterior circulation diseases
- MMSE \< 26, which is a cut-off value for mild cognitive impairment
- severe systemic diseases and neuropsychiatric diseases (such as congestive heart failure and history of stroke)
- any contraindications for MRI scan (e.g., metal implants)
Key Trial Info
Start Date :
December 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05292729
Start Date
December 1 2021
End Date
July 1 2022
Last Update
March 23 2022
Active Locations (1)
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1
the first affiliated hospital of Zhejiang university
Hangzhou, Zhejiang, China, 310016