Status:
UNKNOWN
Effect of Genetic Polymorphisms of UGT on the PKs of Indapamide in Egyptians
Lead Sponsor:
Ain Shams University
Conditions:
Pharmacogenomics
Eligibility:
All Genders
18-45 years
Phase:
PHASE4
Brief Summary
The aim of this works is to investigate the effect of genetic variation of UGT2B7 on human response to treatment with indapamide and its correlation with pharmacokinetic parameters in Egyptian subject...
Detailed Description
Indapamide is a thiazide-type diuretic commonly prescribed to treat mild to moderate hypertension. As it has fewer side effects in inducing metabolic derangements than other thiazide diuretics, indapa...
Eligibility Criteria
Inclusion
- Subjects should be healthy adult volunteers with age between (18-45) with normal body weight.
- The volunteers will be asked to provide a complete medical history, and complete a physical examination, laboratory tests (hematology, clinical chemistry, urinalysis, serology (including hepatitis B surface antigen, anti-hepatitis C virus and antihuman immunodeficiency virus antibody)
Exclusion
- Treatment with any known enzyme -inducing /inhibiting agent within 30 days prior to the start of the study and throughout the study.
- Subjects who have taken any medication less than two weeks of the trials starting date
- Susceptibility to allergic reaction to study drugs
- Any prior surgery of the gastrointestinal tract that may interfere with drug absorption
- Gastrointestinal diseases
- Renal diseases
- Pancreatic disease including diabetes
- Hepatic diseases
- Hematological diseases or pulmonary diseases
- Abnormal laboratory values
- Subject who have donated blood or who have been involved in multiple dosing study requiring a large volume of blood (more than 500 ml) to be drawn within 6 weeks preceding the start of the study.
Key Trial Info
Start Date :
March 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2022
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT05294484
Start Date
March 15 2022
End Date
October 1 2022
Last Update
March 24 2022
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.